Proteomics

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Immuno-Transcriptomic Profiling Identifies Actionable Alterations in Pediatric Solid Malignancies

ABSTRACT: Immuno-Transcriptomic Profiling Identifies Actionable Alterations in Pediatric Solid Malignancies

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Yue Andy Qi  

LAB HEAD: Javed Khan, M.D.

PROVIDER: PXD017130 | Pride | 2021-12-07

REPOSITORIES: Pride

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Publications

Immuno-transcriptomic profiling of extracranial pediatric solid malignancies.

Brohl Andrew S AS   Sindiri Sivasish S   Wei Jun S JS   Milewski David D   Chou Hsien-Chao HC   Song Young K YK   Wen Xinyu X   Kumar Jeetendra J   Reardon Hue V HV   Mudunuri Uma S US   Collins Jack R JR   Nagaraj Sushma S   Gangalapudi Vineela V   Tyagi Manoj M   Zhu Yuelin J YJ   Masih Katherine E KE   Yohe Marielle E ME   Shern Jack F JF   Qi Yue Y   Guha Udayan U   Catchpoole Daniel D   Orentas Rimas J RJ   Kuznetsov Igor B IB   Llosa Nicolas J NJ   Ligon John A JA   Turpin Brian K BK   Leino Daniel G DG   Iwata Shintaro S   Andrulis Irene L IL   Wunder Jay S JS   Toledo Silvia R C SRC   Meltzer Paul S PS   Lau Ching C   Teicher Beverly A BA   Magnan Heather H   Ladanyi Marc M   Khan Javed J  

Cell reports 20211101 8

We perform an immunogenomics analysis utilizing whole-transcriptome sequencing of 657 pediatric extracranial solid cancer samples representing 14 diagnoses, and additionally utilize transcriptomes of 131 pediatric cancer cell lines and 147 normal tissue samples for comparison. We describe patterns of infiltrating immune cells, T cell receptor (TCR) clonal expansion, and translationally relevant immune checkpoints. We find that tumor-infiltrating lymphocytes and TCR counts vary widely across canc  ...[more]

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