T-cell alloreactivity to HLA-DP is regulated by peptide repertoire divergence and HLA-DM mediated editing
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ABSTRACT: Analysis of the peptide repertoires eluted from different HLA-DP molecules expressed in HeLa cells co-expressing Invariant chain either with or without HLA-DM as components of the HLA class II processing machinery. Divergence of the immunopeptidomes and the impact of HLA-DM were investigated in relation to the capacity of HLA-DP molecules to elicit alloreactive T-cell responses.
INSTRUMENT(S): Orbitrap Fusion Lumos, LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Pietro Crivello
LAB HEAD: Katharina Fleischhauer
PROVIDER: PXD017154 | Pride | 2022-11-21
REPOSITORIES: Pride
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