Hepatocyte-specific knockout of Nicotinamide phosphoribosyltransferase increases susceptibility for liver fibrosis in mice

ABSTRACT: We investigated the plasma and liver proteome changes in liver fibrosis in mice induced by hepatocyte-specific knockout of nicotinamide phosphoribosyltransferase (Nampt) upon a low-methionine, choline-free 60% high-fat (MCD) diet at multiple time points. We also investigated whether supplementation with nicotinamide riboside could alleviate liver injury and how the liver proteome changes upon NR supplementation.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Plasma, Liver

DISEASE(S): Liver Inflammation,Fatty Liver Disease

SUBMITTER: Lili Niu  

LAB HEAD: Matthias Mann

PROVIDER: PXD017170 | Pride | 2021-11-04

REPOSITORIES: Pride