Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Cell, Blood Plasma
DISEASE(S): Atherosclerosis
SUBMITTER: Valentin Gogonea
LAB HEAD: Stanley L. Hazen
PROVIDER: PXD017226 | Pride | 2020-03-02
REPOSITORIES: Pride
Zamanian-Daryoush Maryam M Gogonea Valentin V DiDonato Anthony J AJ Buffa Jennifer A JA Choucair Ibrahim I Levison Bruce S BS Hughes Randall A RA Ellington Andrew D AD Huang Ying Y Li Xinmin S XS DiDonato Joseph A JA Hazen Stanley L SL
The Journal of biological chemistry 20200225 15
Apolipoprotein A-I (apoA-I) is the major protein constituent of high-density lipoprotein (HDL) and a target of myeloperoxidase-dependent oxidation in the artery wall. In atherosclerotic lesions, apoA-I exhibits marked oxidative modifications at multiple sites, including Trp<sup>72</sup> Site-specific mutagenesis studies have suggested, but have not conclusively shown, that oxidative modification of Trp<sup>72</sup> of apoA-I impairs many atheroprotective properties of this lipoprotein. Herein, w ...[more]