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Plasma Biomarkers for VX exposure in guinea pigs

ABSTRACT: Biomarker discovery using plasma obtained from exposed guinea pigs (N=6) exposed to VX.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Cavia Porcellus (guinea Pig)

TISSUE(S): Blood Plasma

SUBMITTER: Trevor Glaros

LAB HEAD: Trevor Glaros

PROVIDER: PXD017254 | Pride | 2020-08-03

REPOSITORIES: Pride

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Publications

Discovery of treatment for nerve agents targeting a new metabolic pathway.

Glaros Trevor T Dhummakupt Elizabeth S ES Rizzo Gabrielle M GM McBride Ethan E Carmany Daniel O DO Wright Linnzi K M LKM Forster Jeffry S JS Renner Julie A JA Moretz Ruth W RW Dorsey Russell R Marten Mark R MR Huso Walker W Doan Alexander A Dorsey Carrie D CD Phillips Christopher C Benton Bernard B Mach Phillip M PM

Archives of toxicology 20200727 9

The inhibition of acetylcholinesterase is regarded as the primary toxic mechanism of action for chemical warfare agents. Recently, there have been numerous reports suggesting that metabolic processes could significantly contribute to toxicity. As such, we applied a multi-omics pipeline to generate a detailed cascade of molecular events temporally occurring in guinea pigs exposed to VX. Proteomic and metabolomic profiling resulted in the identification of several enzymes and metabolic precursors ...[more]

PMID: 32720192

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An LCMS-based untargeted metabolomics protocol for cochlear perilymph: highlighting metabolic effects of hydrogen gas on the inner ear of noise exposed Guinea pigs

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2021-10-06 | MTBLS2418 | MetaboLights

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