Dataset Information
Consequences of Cyp2c44 deletion in the polyoma middle T (PyMT) breast cancer tumor proteome
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Primary Cell
SUBMITTER: 
Ilka Wittig
LAB HEAD: Ingrid Fleming
PROVIDER: PXD017336 | Pride | 2020-03-03
REPOSITORIES: Pride
Publications
Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 20200302 11
Arachidonic acid epoxides generated by cytochrome P450 (CYP) enzymes have been linked to increased tumor growth and metastasis, largely on the basis of overexpression studies and the application of exogenous epoxides. Here we studied tumor growth and metastasis in Cyp2c44<sup>-/-</sup> mice crossed onto the polyoma middle T oncogene (PyMT) background. The resulting PyMT<sup>2c44</sup> mice developed more primary tumors earlier than PyMT mice, with increased lymph and lung metastasis. Primary tum ...[more]
