Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion, Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Heart, Skeletal Muscle
SUBMITTER: Marieluise Kirchner
LAB HEAD: Michael Gotthardt
PROVIDER: PXD017341 | Pride | 2020-05-18
REPOSITORIES: Pride
Rudolph Franziska F Fink Claudia C Hüttemeister Judith J Kirchner Marieluise M Radke Michael H MH Lopez Carballo Jacobo J Wagner Eva E Kohl Tobias T Lehnart Stephan E SE Mertins Philipp P Gotthardt Michael M
Nature communications 20200619 1
Proximity proteomics has greatly advanced the analysis of native protein complexes and subcellular structures in culture, but has not been amenable to study development and disease in vivo. Here, we have generated a knock-in mouse with the biotin ligase (BioID) inserted at titin's Z-disc region to identify protein networks that connect the sarcomere to signal transduction and metabolism. Our census of the sarcomeric proteome from neonatal to adult heart and quadriceps reveals how perinatal signa ...[more]