Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Heart
DISEASE(S): Cardiovascular System Disease
SUBMITTER: D Kent Arrell
LAB HEAD: Andre Terzic, MD, PhD
PROVIDER: PXD017381 | Pride | 2020-03-23
REPOSITORIES: Pride
Arrell D Kent DK Rosenow Christian S CS Yamada Satsuki S Behfar Atta A Terzic Andre A
NPJ Regenerative medicine 20200312
Cardiopoietic stem cells have reached advanced clinical testing for ischemic heart failure. To profile their molecular influence on recipient hearts, systems proteomics was here applied in a chronic model of infarction randomized with and without human cardiopoietic stem cell treatment. Multidimensional label-free tandem mass spectrometry resolved and quantified 3987 proteins constituting the cardiac proteome. Infarction altered 450 proteins, reduced to 283 by stem cell treatment. Notably, cell ...[more]