Characterization of signaling pathways associated with pancreatic beta-cell adaptive flexibility in compensation of obesity-linked diabetes in db/db miceCharacterization of signaling pathways associated with pancreatic β-cell adaptive flexibility in compensation of obesity-linked diabetes in db/db mice

ABSTRACT: To characterize the signaling mechanisms underlying beta-cell dysfunction in db/db mice and their return to a more “normal” beta-cell phenotype, we applied a mass spectrometry-based quantitative phosphophoproteomics and sialiomics(sialylated N-linked glycopeptides) approach to normal and db/db beta-cells from hyperglycemic and euglycemic environments.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Islet Of Langerhans, Pancreatic Islet Cell

DISEASE(S): Type 2 Diabetes Mellitus

SUBMITTER: Taewook Kang  

LAB HEAD: Martin R. Larsen

PROVIDER: PXD017469 | Pride | 2020-05-19

REPOSITORIES: Pride