Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Melanocyte, Cell Culture
DISEASE(S): Melanoma
SUBMITTER: Chiara Francavilla
LAB HEAD: Chiara Francavilla
PROVIDER: PXD017487 | Pride | 2023-03-10
REPOSITORIES: Pride
Wilcock Daniel J DJ Badrock Andrew P AP Wong Chun W CW Owen Rhys R Guerin Melissa M Southam Andrew D AD Johnston Hannah H Telfer Brian A BA Fullwood Paul P Watson Joanne J Ferguson Harriet H Ferguson Jennifer J Lloyd Gavin R GR Jankevics Andris A Dunn Warwick B WB Wellbrock Claudia C Lorigan Paul P Ceol Craig C Francavilla Chiara C Smith Michael P MP Hurlstone Adam F L AFL
Cell reports 20220601 12
Dysregulated cellular metabolism is a cancer hallmark for which few druggable oncoprotein targets have been identified. Increased fatty acid (FA) acquisition allows cancer cells to meet their heightened membrane biogenesis, bioenergy, and signaling needs. Excess FAs are toxic to non-transformed cells but surprisingly not to cancer cells. Molecules underlying this cancer adaptation may provide alternative drug targets. Here, we demonstrate that diacylglycerol O-acyltransferase 1 (DGAT1), an enzym ...[more]