Proteomics of of SLC25A1 and SLC25A4 null cells using TMT
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
SUBMITTER: 
Duc Duong
LAB HEAD: Victor Faundez
PROVIDER: PXD017501 | Pride | 2023-05-31
REPOSITORIES: Pride
Publications
APOE expression and secretion are modulated by mitochondrial dysfunction.
Wynne Meghan E ME Ogunbona Oluwaseun O Lane Alicia R AR Gokhale Avanti A Zlatic Stephanie A SA Xu Chongchong C Wen Zhexing Z Duong Duc M DM Rayaprolu Sruti S Ivanova Anna A Ortlund Eric A EA Dammer Eric B EB Seyfried Nicholas T NT Roberts Blaine R BR Crocker Amanda A Shanbhag Vinit V Petris Michael M Senoo Nanami N Kandasamy Selvaraju S Claypool Steven Michael SM Barrientos Antoni A Wingo Aliza A Wingo Thomas S TS Rangaraju Srikant S Levey Allan I AI Werner Erica E Faundez Victor V
eLife 20230512
Mitochondria influence cellular function through both cell-autonomous and non-cell autonomous mechanisms, such as production of paracrine and endocrine factors. Here, we demonstrate that mitochondrial regulation of the secretome is more extensive than previously appreciated, as both genetic and pharmacological disruption of the electron transport chain caused upregulation of the Alzheimer's disease risk factor apolipoprotein E (APOE) and other secretome components. Indirect disruption of the ele ...[more]
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