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White body nanoLC ESI-MS/MS analysis in the cephalopod Sepia officinalis

ABSTRACT: Cephalopods, like other Protostomes, lack an adaptive immune system and only rely on an innate immune system. The main immune cells are haemocytes, able to respond to pathogens and external attacks. First reports based on morphological observations suggested that the white body located in the optic sinuses of cuttlefish was at the origin of haemocytes. We performed a shotgun analysis of the proteome of the white body in cutllefish in order to confirm haematopoietic function and explore additional function.

INSTRUMENT(S): Bruker Daltonics maXis series

ORGANISM(S): Sepia Officinalis

TISSUE(S): Hematopoietic System

SUBMITTER: benoit bernay

LAB HEAD: Céline Zatylny-Gaudin

PROVIDER: PXD017509 | Pride | 2020-07-10

REPOSITORIES: Pride

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-Omic Analysis of the <i>Sepia officinalis</i> White Body: New Insights into Multifunctionality and Haematopoiesis Regulation.

Benoist Louis L Corre Erwan E Bernay Benoit B Henry Joel J Zatylny-Gaudin Céline C

Journal of proteome research 20200722 8

Cephalopods, like other protostomes, lack an adaptive immune system and only rely on an innate immune system. The main immune cells are haemocytes (Hcts), which are able to respond to pathogens and external attacks. First reports based on morphological observations revealed that the white body (WB) located in the optic sinuses of cuttlefish was the origin of Hcts. Combining transcriptomic and proteomic analyses, we identified several factors known to be involved in haematopoiesis in vertebrate s ...[more]

PMID: 32643382

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