Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Blood Cell, Bone Marrow
SUBMITTER: Thomas Bock
LAB HEAD: Alexander Schmidt
PROVIDER: PXD017657 | Pride | 2020-04-08
REPOSITORIES: Pride
Leonards Katharina K Almosailleakh Marwa M Tauchmann Samantha S Bagger Frederik Otzen FO Thirant Cécile C Juge Sabine S Bock Thomas T Méreau Hélène H Bezerra Matheus F MF Tzankov Alexandar A Ivanek Robert R Losson Régine R Peters Antoine H F M AHFM Mercher Thomas T Schwaller Juerg J
Nature communications 20200612 1
The nuclear receptor binding SET domain protein 1 (NSD1) is recurrently mutated in human cancers including acute leukemia. We show that NSD1 knockdown alters erythroid clonogenic growth of human CD34<sup>+</sup> hematopoietic cells. Ablation of Nsd1 in the hematopoietic system of mice induces a transplantable erythroleukemia. In vitro differentiation of Nsd1<sup>-/-</sup> erythroblasts is majorly impaired despite abundant expression of GATA1, the transcriptional master regulator of erythropoiesi ...[more]