Dataset Information
Human macrophages LC-MS/MS in the proteome and secretome
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Velos Plus
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Macrophage
DISEASE(S): Cardiovascular System Disease
SUBMITTER: 
Maciej Suski
LAB HEAD: Rafał Olszanecki
PROVIDER: PXD017787 | Pride | 2020-10-15
REPOSITORIES: Pride
Publications
Decrease of the pro-inflammatory M1-like response by inhibition of dipeptidyl peptidases 8/9 in THP-1 macrophages - quantitative proteomics of the proteome and secretome.
Molecular immunology 20200929
<h4>Background</h4>Cellular peptidases are an emerging target of novel pharmacological strategies in inflammatory diseases and cancer. In this context, the dipeptidyl peptidases 8 and 9 (DPP8/9) have gained special attention due to their activities in the immune cells. However, in spite of more than hundred protein substrates identified to date by mass spectrometry-based analysis, the cellular DPP8/9 functions are still elusive.<h4>Methods</h4>We applied the proteomic approach (iTRAQ-2DLC-MS/MS) ...[more]
