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LC-MSMS of postmenopausal with low BMD

ABSTRACT: Postmenopausal osteoporosis (PMOP) is a major global public health concern and older women are more susceptible to experiencing fragility fractures. Our study investigated the associations between circulating proteins with bone mineral density (BMD) in postmenopausal women with or without low BMD (osteoporosis and osteopenia) to explore the pathogenesis of PMOP and discover novel biomarkers for this disease..

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood

DISEASE(S): Osteoporosis

SUBMITTER: Jihan Wang

LAB HEAD: Jihan Wang

PROVIDER: PXD017804 | Pride | 2020-04-27

REPOSITORIES: Pride

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Proteomic profiling analysis of postmenopausal osteoporosis and osteopenia identifies potential proteins associated with low bone mineral density.

Huang Dageng D Wang Yangyang Y Lv Jing J Yan Yuzhu Y Hu Ya Y Liu Cuicui C Zhang Feng F Wang Jihan J Hao Dingjun D

PeerJ 20200414

Postmenopausal osteoporosis (PMOP) is a major global public health concern and older women are more susceptible to experiencing fragility fractures. Our study investigated the associations between circulating proteins with bone mineral density (BMD) in postmenopausal women with or without low BMD (osteoporosis and osteopenia) using a tandem mass tag (TMT) labeling proteomic experiment and parallel reaction monitoring testing. Across all plasma samples, we quantitatively measured 1,092 proteins, ...[more]

PMID: 32328356

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