Name: A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis
Keywords: Staphylococcus pro-apoptotic peptide

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A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis

ABSTRACT: A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Staphylococcus Sp. Kdm4

DISEASE(S): Severe Acute Respiratory Syndrome

SUBMITTER: PETER YAU

LAB HEAD: Isaac K. O. Cann

PROVIDER: PXD017818 | Pride | 2020-04-22

REPOSITORIES: Pride

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A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis.

D'Alessandro-Gabazza Corina N CN Kobayashi Tetsu T Yasuma Taro T Toda Masaaki M Kim Heejin H Fujimoto Hajime H Hataji Osamu O Takeshita Atsuro A Nishihama Kota K Okano Tomohito T Okano Yuko Y Nishii Yoichi Y Tomaru Atsushi A Fujiwara Kentaro K D'Alessandro Valeria Fridman VF Abdel-Hamid Ahmed M AM Ren Yudong Y Pereira Gabriel V GV Wright Christy L CL Hernandez Alvaro A Fields Christopher J CJ Yau Peter M PM Wang Shujie S Mizoguchi Akira A Fukumura Masayuki M Ohtsuka Junpei J Nosaka Tetsuya T Kataoka Kensuke K Kondoh Yasuhiro Y Wu Jing J Kawagishi Hirokazu H Yano Yutaka Y Mackie Roderick I RI Cann Isaac I Gabazza Esteban C EC

Nature communications 20200324 1

Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disease of unknown etiology; however, apoptosis of lung alveolar epithelial cells plays a role in disease progression. This intractable disease is associated with increased abundance of Staphylococcus and Streptococcus in the lungs, yet their roles in disease pathogenesis remain elusive. Here, we report that Staphylococcus nepalensis releases corisin, a peptide conserved in diverse staphylococci, to induce apoptosis of lung epithelial ce ...[more]

PMID: 32210242

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