High Fructose-Driven Epigenetic and Metabolic Reprogramming in Glomerular Podocyte

ABSTRACT: High fructose diet has been proposed as a major contributor to metabolic syndrome, which is usually accompanied with proteinuria due to glomerular podocyte injury. However, the underlying pathological mechanisms of fructose-induced podocyte injury remain elusive. In this study, we have used an iTRAQ based quantitative proteomic strategy to comprehensively characterize the dynamic proteome changes in glomeruli of high fructose-fed rats, and revealed global fructose-induced glomerular metabolic reprogramming at four different stages during the progression of high fructose modeling.

INSTRUMENT(S):

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Kidney

SUBMITTER: Lei Fang  

LAB HEAD: Lei Fang

PROVIDER: PXD017849 | Pride | 2022-05-19

REPOSITORIES: Pride