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Identification and characterization of novel peptide components in the venom of Indian marine cone snails

ABSTRACT: The project is aimed at the identification of conotoxins and conopeptides from the venom of marine cone snails found in the Indian coastal waters. Peptides of novel sequences will be further characterized in terms of structural and physico-chemical properties by NMR spectroscopy and other biophysical methods and will be studied for the abilities to elicit pharmacological responses against cellular targets.

INSTRUMENT(S): ultraflex

ORGANISM(S): Conus Caracteristicus Conus Zonatus

TISSUE(S): Epithelial Cell, Venom Gland

SUBMITTER: Siddhartha Sarma

LAB HEAD: Prof. Siddhartha P Sarma

PROVIDER: PXD017882 | Pride | 2021-09-09

REPOSITORIES: Pride

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Publications

Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors.

Mohan Madhan Kumar MK Abraham Nikita N R P Rajesh R Jayaseelan Benjamin Franklin BF Ragnarsson Lotten L Lewis Richard J RJ Sarma Siddhartha P SP

The Journal of biological chemistry 20200331 20

Conopeptides are neurotoxic peptides in the venom of marine cone snails and have broad therapeutic potential for managing pain and other conditions. Here, we identified the single-disulfide peptides Czon1107 and Cca1669 from the venoms of Conus zonatus and Conus caracteristicus, respectively. We observed that Czon1107 strongly inhibits the human α3β4 (IC50 15.7 ± 3.0 μm) and α7 (IC50 77.1 ± 0.05 μm) nicotinic acetylcholine receptor (nAChR) subtypes, but the ac ...[more]

PMID: 32234761

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