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Integrin adhesion complexes formed on different basement membrane ligands

ABSTRACT: Adhesion complexes isolated from cells in culture. Podocytes were attached to different extracellular matrix ligands and adhesion complex isolated.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture, Kidney

SUBMITTER: UoC Randles

LAB HEAD: Rachel Lennon

PROVIDER: PXD017913 | Pride | 2020-03-09

REPOSITORIES: Pride

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Basement membrane ligands initiate distinct signalling networks to direct cell shape.

Randles Michael J MJ Lausecker Franziska F Humphries Jonathan D JD Byron Adam A Clark Simon J SJ Miner Jeffrey H JH Zent Roy R Humphries Martin J MJ Lennon Rachel R

Matrix biology : journal of the International Society for Matrix Biology 20200306

Cells have evolved mechanisms to sense the composition of their adhesive microenvironment. Although much is known about general mechanisms employed by adhesion receptors to relay signals between the extracellular environment and the cytoskeleton, the nuances of ligand-specific signalling remain undefined. Here, we investigated how glomerular podocytes, and four other basement membrane-associated cell types, respond morphologically to different basement membrane ligands. We defined the compositio ...[more]

PMID: 32147508

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