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Identifying interactors through BioID2 in rat cortical neurons

ABSTRACT: Utilizing proximity labeling technolgy coupled to LC-MS/MS to identify TTBK1 and TTBK2 unique interactors in rat cortical neurons

INSTRUMENT(S):

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Primary Cell, Early Embryonic Cell

DISEASE(S): Disease Free

SUBMITTER: Bekim Bajrami

LAB HEAD: Bekim Bajrami

PROVIDER: PXD017937 | Pride | 2025-05-06

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	Experiment-1a_mzTab.mzTab	Mztab
	Experiment-1a_proteinGroups.txt	Txt
	Experiment-1b_mzTab.mzTab	Mztab
	Experiment-1b_proteinGroups.txt	Txt
	QP1_181026_BB1_S_BioID_BioID2_01_002.mzML	Mzml

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Publications

Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.

Bao Channa C Bajrami Bekim B Marcotte Douglas J DJ Chodaparambil Jayanth V JV Kerns Hannah M HM Henderson Jaclyn J Wei Ru R Gao Benbo B Dillon Gregory M GM

Cellular and molecular neurobiology 20200518 4

Tau-tubulin kinase 1 (TTBK1) is a CNS-specific, kinase that has been implicated in the pathological phosphorylation of tau in Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD). TTBK1 is a challenging therapeutic target because it shares a highly conserved catalytic domain with its homolog, TTBK2, a ubiquitously expressed kinase genetically linked to the disease spinocerebellar ataxia type 11. The present study attempts to elucidate the functional distinctions between the TTBK isoforms a ...[more]

PMID: 32424773

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