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TTBK1/TTBK2 Phosphoproteomics in mouse cortical neurons

ABSTRACT: TTBK1 and TTBK2 unique substrate identifications in mouse cortical neurons through global phosphoproteomics studies. shRNA for both TTBK1 or TTBK2 was used to treat mouse cortical neurons, to knockdown each kinase.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Early Embryonic Cell

DISEASE(S): Neuroblastoma

SUBMITTER: Bekim Bajrami

LAB HEAD: Bekim Bajrami

PROVIDER: PXD017938 | Pride | 2025-05-06

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	Phospho__ST_Sites.txt	Txt
	QH3_190614_BB1_S_TTBK1-2_Phospho_RatNeurons_shRNA_Control_01_001.mzML	Mzml
	QH3_190614_BB1_S_TTBK1-2_Phospho_RatNeurons_shRNA_Control_01_001.raw	Raw
	QH3_190614_BB1_S_TTBK1-2_Phospho_RatNeurons_shRNA_Control_02_007.mzML	Mzml
	QH3_190614_BB1_S_TTBK1-2_Phospho_RatNeurons_shRNA_Control_02_007.raw	Raw

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1 - 5 of 22

Publications

Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.

Bao Channa C Bajrami Bekim B Marcotte Douglas J DJ Chodaparambil Jayanth V JV Kerns Hannah M HM Henderson Jaclyn J Wei Ru R Gao Benbo B Dillon Gregory M GM

Cellular and molecular neurobiology 20200518 4

Tau-tubulin kinase 1 (TTBK1) is a CNS-specific, kinase that has been implicated in the pathological phosphorylation of tau in Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD). TTBK1 is a challenging therapeutic target because it shares a highly conserved catalytic domain with its homolog, TTBK2, a ubiquitously expressed kinase genetically linked to the disease spinocerebellar ataxia type 11. The present study attempts to elucidate the functional distinctions between the TTBK isoforms a ...[more]

PMID: 32424773

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