Dataset Information

Identification of TTBK1 autophosphorylation sites in HEK293 cells

ABSTRACT: Wild type or kinase dead TTBK1 kinase is overexpressed in HEK293 cells, IP and seperated on SDSPAGE gel. TTBK1 corresponding bands are cut and analyzed on shotgun proteomics.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

DISEASE(S): Disease Free

SUBMITTER: Bekim Bajrami

LAB HEAD: Bekim Bajrami

PROVIDER: PXD017939 | Pride | 2025-05-06

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	Phospho__ST_Sites.txt	Txt
	QP1_171109_BB1_S_TTBK1_AutoPhos_KD_Bio914_01_013.mzML	Mzml
	QP1_171109_BB1_S_TTBK1_AutoPhos_KD_Bio914_01_013.raw	Raw
	QP1_171109_BB1_S_TTBK1_AutoPhos_KD_Bio914_02_014.mzML	Mzml
	QP1_171109_BB1_S_TTBK1_AutoPhos_KD_Bio914_02_014.raw	Raw

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Publications

Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms.

Bao Channa C Bajrami Bekim B Marcotte Douglas J DJ Chodaparambil Jayanth V JV Kerns Hannah M HM Henderson Jaclyn J Wei Ru R Gao Benbo B Dillon Gregory M GM

Cellular and molecular neurobiology 20200518 4

Tau-tubulin kinase 1 (TTBK1) is a CNS-specific, kinase that has been implicated in the pathological phosphorylation of tau in Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD). TTBK1 is a challenging therapeutic target because it shares a highly conserved catalytic domain with its homolog, TTBK2, a ubiquitously expressed kinase genetically linked to the disease spinocerebellar ataxia type 11. The present study attempts to elucidate the functional distinctions between the TTBK isoforms a ...[more]

PMID: 32424773

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