Identifying dynamic protein and RNA proximity interaction networks of actinin reveals RNA-binding and metabolic regulatory mechanisms

ABSTRACT: We deployed proximity-dependent biotinylation to identify actinin proximity proteins and RNA transcripts in human cardiomyocytes to reveal new functions of the actin cytoskeleton. We identified 285 proximity protein partners including unexpected effectors of RNA-binding and metabolism, and interrogated dynamic partners using a sarcomere assembly model.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Feria Ladha  

LAB HEAD: J. Travis Hinson

PROVIDER: PXD018040 | Pride | 2022-02-15

REPOSITORIES: Pride