Dataset Information

Mouse early diabetic nephropathy LC-MS/MS analysis

ABSTRACT: The present study aims to evaluate the alterations induced by type I diabetes and the associated hyperglycemia on the proteome of renal tissue using a transgenic experimental animal model. Diabetic and non-diabetic kidney samples were analyzed by liquid nano-chromatography mass spectrometry and protein abundance was evaluated bylabel free quantification.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Kidney

DISEASE(S): Disease Free,Diabetes Mellitus

SUBMITTER: Felicia Antohe

LAB HEAD: Felicia Antohe

PROVIDER: PXD018053 | Pride | 2020-09-24

REPOSITORIES: Pride

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Publications

Diabetic nephropathy associates with deregulation of enzymes involved in kidney sulphur metabolism.

Uyy Elena E Suica Viorel Iulian VI Boteanu Raluca Maria RM Safciuc Florentina F Cerveanu-Hogas Aurel A Ivan Luminita L Stavaru Crina C Simionescu Maya M Antohe Felicia F

Journal of cellular and molecular medicine 20200916 20

Nephropathy is a major chronic complication of diabetes. A crucial role in renal pathophysiology is played by hydrogen sulphide (H2 S) that is produced excessively by the kidney; however, the data regarding H2 S bioavailability are inconsistent. We hypothesize that early type 1 diabetes (T1D) increases H2 S production by a mechanism involving hyperglycaemia-induced alterations in sulphur metabolism. Plasma and kidney tissue collected from T1D double transgenic mi ...[more]

PMID: 32935914

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Dataset Information

Mouse early diabetic nephropathy LC-MS/MS analysis

Publications

Diabetic nephropathy associates with deregulation of enzymes involved in kidney sulphur metabolism.

Similar Datasets

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