Proteomics

Dataset Information

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The interactome of BTN3A1 (Butyrophilin Subfamily 3 Member A1)


ABSTRACT: In this study we dissected the BTN3A1 interactome before or after the treatment with pamidronate to gain mehcanistic insights into the gamma9/delta2 T cell dependent recognition of target cells. Our approach relied on affinity purification couple with mass spectrometry from a BTN3A knock-out cell line stably reconstituted with FLAG-BTN3A1. Our findings revealed an important role of cellular trafficking of BTN3A1 in the gamma9/delta2 TCR-induced T cell activation.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Domenico Fasci  

LAB HEAD: Albert J. R. Heck

PROVIDER: PXD018055 | Pride | 2020-06-05

REPOSITORIES: Pride

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Publications


γ9δ2T cells play a major role in cancer immune surveillance, yet the clinical translation of their in vitro promise remains challenging. To address limitations of previous clinical attempts using expanded γ9δ2T cells, we explored the clonal diversity of γ9δ2T cell repertoires and characterized their target. We demonstrated that only a fraction of expanded γ9δ2T cells was active against cancer cells and that activity of the parental clone, or functional avidity of selected γ9δ2 T cell receptors (  ...[more]

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