Transcriptome and proteome profiling of motor neuron model subjected to protein misfolding stress

ABSTRACT: To identify molecular differences between closely related motor neurons relevant for understanding of neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS), we exploited induced cranial and spinal motor neuron populations from mouse embryonic stem cells. We performed a large scale time-dependent TMT-based proteomics analysis in the presence and absence of protein misfolding stress. We profiled ~8,600 proteins from two different motor neuron cell lines, measured in two replicates and three time points.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Embryonic Stem Cell

SUBMITTER: Christine Vogel  

LAB HEAD: Christine Vogel

PROVIDER: PXD018070 | Pride | 2024-03-06

REPOSITORIES: Pride