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Cell wall and secretome of Candida albicans WT, hir1delta/delta strain, and HIR1 complemented mutant

ABSTRACT: Cell wall and secretome of Candida albicans WT, hir1delta/delta strain, and HIR1 complemented mutant using SWATH MS.

INSTRUMENT(S):

ORGANISM(S): Candida Albicans (yeast)

SUBMITTER: Lucia Zacchi

LAB HEAD: Lucia Florencia Zacchi

PROVIDER: PXD018163 | Pride | 2022-02-15

REPOSITORIES: Pride

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			Action	DRS
	20200318_Mahler_Luci_Calb_Exp3_11_sec.wiff	Wiff
	20200318_Mahler_Luci_Calb_Exp3_11_sec.wiff.scan	Wiff
	20200318_Mahler_Luci_Calb_Exp3_11b_cw.wiff	Wiff
	20200318_Mahler_Luci_Calb_Exp3_11b_cw.wiff.scan	Wiff
	20200318_Mahler_Luci_Calb_Exp3_12_sec.wiff	Wiff

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Publications

The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence.

Jenull Sabrina S Mair Theresia T Tscherner Michael M Penninger Philipp P Zwolanek Florian F Silao Fitz-Gerald S FS de San Vicente Kontxi Martinez KM Riedelberger Michael M Bandari Naga C NC Shivarathri Raju R Petryshyn Andriy A Chauhan Neeraj N Zacchi Lucia F LF -Landmann Salomé LeibundGut SL Ljungdahl Per O PO Kuchler Karl K

Cell reports 20210701 3

Adaptation to changing environments and immune evasion is pivotal for fitness of pathogens. Yet, the underlying mechanisms remain largely unknown. Adaptation is governed by dynamic transcriptional re-programming, which is tightly connected to chromatin architecture. Here, we report a pivotal role for the HIR histone chaperone complex in modulating virulence of the human fungal pathogen Candida albicans. Genetic ablation of HIR function alters chromatin accessibility linked to aberrant transcript ...[more]

PMID: 34289370

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