Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: Cheng Huang
LAB HEAD: Adam Rose
PROVIDER: PXD018205 | Pride | 2020-06-15
REPOSITORIES: Pride
Yap Yann W YW Rusu Patricia M PM Chan Andrea Y AY Fam Barbara C BC Jungmann Andreas A Solon-Biet Samantha M SM Barlow Christopher K CK Creek Darren J DJ Huang Cheng C Schittenhelm Ralf B RB Morgan Bruce B Schmoll Dieter D Kiens Bente B Piper Matthew D W MDW Heikenwälder Mathias M Simpson Stephen J SJ Bröer Stefan S Andrikopoulos Sofianos S Müller Oliver J OJ Rose Adam J AJ
Nature communications 20200609 1
Dietary protein dilution (DPD) promotes metabolic-remodelling and -health but the precise nutritional components driving this response remain elusive. Here, by mimicking amino acid (AA) supply from a casein-based diet, we demonstrate that restriction of dietary essential AA (EAA), but not non-EAA, drives the systemic metabolic response to total AA deprivation; independent from dietary carbohydrate supply. Furthermore, systemic deprivation of threonine and tryptophan, independent of total AA supp ...[more]