PXD018224 - Multi-Omics’ Defines Unstable and Stable Atherosclerotic Plaque Signatures and Identifies Novel Targets for Plaque Stabilisation - OmicsDI

Proteomics

Dataset Information

Multi-Omics’ Defines Unstable and Stable Atherosclerotic Plaque Signatures and Identifies Novel Targets for Plaque Stabilisation

ABSTRACT: The rupture of unstable atherosclerotic plaques, leading to debilitating or fatal thrombotic events, are a major health concern worldwide. Limited understanding as to the molecular drivers of plaque destabilisation and rupture hinders efforts in diagnosis and treatment prior to thrombotic events. Using an advanced pre-clinical model (tandem stenosis), we characterise the molecular signatures associated with plaque instability in atherosclerotic vessels.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

DISEASE(S): Cardiovascular System Disease

SUBMITTER: david greening

LAB HEAD: David Greening

PROVIDER: PXD018224 | Pride | 2023-07-24

REPOSITORIES: Pride

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Publications

Quantitative proteomic landscape of unstable atherosclerosis identifies molecular signatures and therapeutic targets for plaque stabilization.

Chen Yung-Chih YC Smith Meaghan M Ying Ya-Lan YL Makridakis Manousos M Noonan Jonathan J Kanellakis Peter P Rai Alin A Salim Agus A Murphy Andrew A Bobik Alex A Vlahou Antonia A Greening David W DW Peter Karlheinz K

Communications biology 20230313 1

Atherosclerotic plaque rupture leading to myocardial infarction is a major global health burden. Applying the tandem stenosis (TS) mouse model, which distinctively exhibits the characteristics of human plaque instability/rupture, we use quantitative proteomics to understand and directly compare unstable and stable atherosclerosis. Our data highlight the disparate natures and define unique protein signatures of unstable and stable atherosclerosis. Key proteins and pathway networks are identified ...[more]

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