Proteomics

Dataset Information

0

Crosslinking-MS dataset of the TFIIIC subcomplex tauA with Brf1 and TBP


ABSTRACT: Identification of crosslinks between the subunits tau131, tau95, tau55, Brf1 and TBP

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)

SUBMITTER: Matthias Vorländer  

LAB HEAD: Christoph W Mueller

PROVIDER: PXD018232 | Pride | 2020-12-04

REPOSITORIES: Pride

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Publications

Structure of the TFIIIC subcomplex τA provides insights into RNA polymerase III pre-initiation complex formation.

Vorländer Matthias K MK   Jungblut Anna A   Karius Kai K   Baudin Florence F   Grötsch Helga H   Kosinski Jan J   Müller Christoph W CW  

Nature communications 20200930 1


Transcription factor (TF) IIIC is a conserved eukaryotic six-subunit protein complex with dual function. It serves as a general TF for most RNA polymerase (Pol) III genes by recruiting TFIIIB, but it is also involved in chromatin organization and regulation of Pol II genes through interaction with CTCF and condensin II. Here, we report the structure of the S. cerevisiae TFIIIC subcomplex τA, which contains the most conserved subunits of TFIIIC and is responsible for recruitment of TFIIIB and tra  ...[more]

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