Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell
DISEASE(S): Multiple Myeloma
SUBMITTER: Jana Zecha
LAB HEAD: Bernhard Kuster
PROVIDER: PXD018244 | Pride | 2021-02-18
REPOSITORIES: Pride
Heider Michael M Eichner Ruth R Stroh Jacob J Morath Volker V Kuisl Anna A Zecha Jana J Lawatscheck Jannis J Baek Kheewoong K Garz Anne-Kathrin AK Rudelius Martina M Deuschle Friedrich-Christian FC Keller Ulrich U Lemeer Simone S Verbeek Mareike M Götze Katharina S KS Skerra Arne A Weber Wolfgang A WA Buchner Johannes J Schulman Brenda A BA Kuster Bernhard B Fernández-Sáiz Vanesa V Bassermann Florian F
Molecular cell 20210210 6
The complex architecture of transmembrane proteins requires quality control (QC) of folding, membrane positioning, and trafficking as prerequisites for cellular homeostasis and intercellular communication. However, it has remained unclear whether transmembrane protein-specific QC hubs exist. Here we identify cereblon (CRBN), the target of immunomodulatory drugs (IMiDs), as a co-chaperone that specifically determines chaperone activity of HSP90 toward transmembrane proteins by means of counteract ...[more]