Proteomics

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Characterization of proteome dynamics in individual vascular layers at the early stage of acute sepsis


ABSTRACT: In this study we developed a stable isotope labeled of mammals (SILAM) model coupled to the application of differential systemic decellularization in vivo (DISDIVO) to evaluate the molecular dynamics of whole organism vascular beds at the initial phase of acute sepsis. Three different vascular layers where characterized at the initial stage of sepsis, glycocalyx (GC), endothelial cells (ECs) and smooth muscle cells (SMCs).

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cardiovascular System

DISEASE(S): Bacterial Sepsis

SUBMITTER: Aida Serra  

LAB HEAD: Aida Serra

PROVIDER: PXD018274 | Pride | 2020-10-29

REPOSITORIES: Pride

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