Proteome-scale correlation analysis between urinary extracellular vesicle (uEV) and kidney
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion, Q Exactive
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Urine, Whole Body
SUBMITTER: 
Qi Wu
LAB HEAD: Robert A. Fenton
PROVIDER: PXD018363 | Pride | 2021-07-27
REPOSITORIES: Pride
Publications
Large-Scale Proteomic Assessment of Urinary Extracellular Vesicles Highlights Their Reliability in Reflecting Protein Changes in the Kidney.
Wu Qi Q Poulsen Søren B SB Murali Sathish K SK Grimm Paul R PR Su Xiao-Tong XT Delpire Eric E Welling Paul A PA Ellison David H DH Ellison David H DH Fenton Robert A RA
Journal of the American Society of Nephrology : JASN 20210706 9
<h4>Background</h4>Urinary extracellular vesicles (uEVs) are secreted into urine by cells from the kidneys and urinary tract. Although changes in uEV proteins are used for quantitative assessment of protein levels in the kidney or biomarker discovery, whether they faithfully reflect (patho)physiologic changes in the kidney is a matter of debate.<h4>Methods</h4>Mass spectrometry was used to compare in an unbiased manner the correlations between protein levels in uEVs and kidney tissue from the sa ...[more]
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