Comprehensive proteomics analysis methods: Pre-Invasive Serous Lesions of the Endometrium and Fallopian Tube analyzed and compared

ABSTRACT: We present data from precancerous lesions from the endometrium and fallopian tube of a single patient. Using this complimentary approach, we gained a spatially defined representation of the molecular landscape within these tissue sections, and identified hundreds of proteins within the precancerous, and neighboring healthy regions. The method presented here represent a useful tool to maximize the amount of molecular data acquired from small sample sizes and even single cases, as shown here. Our initial data are indicative of a migratory phenotype in these lesions and warrant further research into their malignant capabilities.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Ovarian Surface Epithelial Cell

DISEASE(S): Malignant Neoplasm Of Ovary

SUBMITTER: Parul Mittal  

LAB HEAD: Prof Peter Hoffmann

PROVIDER: PXD018538 | Pride | 2020-12-02

REPOSITORIES: Pride