Proteomics

Dataset Information

0

Identification of the Cfap206 interactome from mouse testis to identify its role in cilia function


ABSTRACT: Cfap206 was immunoprecipitated from mouse testis to identify the interactome of this protein for further functional studies.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Testis, Sperm

DISEASE(S): Ciliopathy

SUBMITTER: Karsten Boldt  

LAB HEAD: Dr. Karsten Boldt

PROVIDER: PXD018554 | Pride | 2020-05-29

REPOSITORIES: Pride

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Publications

The FOXJ1 target <i>Cfap206</i> is required for sperm motility, mucociliary clearance of the airways and brain development.

Beckers Anja A   Beckers Anja A   Adis Christian C   Schuster-Gossler Karin K   Tveriakhina Lena L   Ott Tim T   Fuhl Franziska F   Hegermann Jan J   Boldt Karsten K   Serth Katrin K   Rachev Ev E   Alten Leonie L   Kremmer Elisabeth E   Ueffing Marius M   Blum Martin M   Gossler Achim A  

Development (Cambridge, England) 20200615 21


Cilia are complex cellular protrusions consisting of hundreds of proteins. Defects in ciliary structure and function, many of which have not been characterised molecularly, cause ciliopathies: a heterogeneous group of human syndromes. Here, we report on the FOXJ1 target gene <i>Cfap206</i>, orthologues of which so far have only been studied in <i>Chlamydomonas</i> and <i>Tetrahymena</i> In mouse and <i>Xenopus</i>, <i>Cfap206</i> was co-expressed with and dependent on <i>Foxj1</i> CFAP206 protei  ...[more]

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