Proteomics

Dataset Information

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Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

ABSTRACT: The molecular networks underlying Alzheimer’s disease (AD) are not well-defined. We present temporal profiling of >14,000 proteins and >34,000 phosphosites at the asymptomatic and symptomatic stages of AD, deep proteomics analysis of transgenic mouse models.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Yuxin Li  

LAB HEAD: Junmin Peng

PROVIDER: PXD018590 | Pride | 2020-04-16

REPOSITORIES: Pride

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Dataset's files

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Action DRS
ad_b1_whp_f10_01.1.pepXML Pepxml
ad_b1_whp_f10_01.raw Raw
ad_b1_whp_f11_01.1.pepXML Pepxml
ad_b1_whp_f11_01.raw Raw
ad_b1_whp_f12_02.1.pepXML Pepxml
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Publications

Alzheimer's disease (AD) displays a long asymptomatic stage before dementia. We characterize AD stage-associated molecular networks by profiling 14,513 proteins and 34,173 phosphosites in the human brain with mass spectrometry, highlighting 173 protein changes in 17 pathways. The altered proteins are validated in two independent cohorts, showing partial RNA dependency. Comparisons of brain tissue and cerebrospinal fluid proteomes reveal biomarker candidates. Combining with 5xFAD mouse analysis,  ...[more]