Targeting LSD1 rewires kinase networks and primes leukaemia cells for kinase inhibitor treatment

ABSTRACT: We show that intrinsic resistance to kinase inhibitors may be reversed by coercing kinase networks into acquiring topologies tolerant to drug sensitivity. Using acute myeloid leukaemia (AML) as a model, we found several antagonists of chromatin modifying enzymes that sensitised cancer cells to kinase inhibitor treatments.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Myeloblast, Peripheral Blood

DISEASE(S): Acute Myeloid Leukemia

SUBMITTER: Maruan Hijazi  

LAB HEAD: Pedro Cutillas

PROVIDER: PXD018603 | Pride | 2022-04-25

REPOSITORIES: Pride