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Proteomic Analysis of Trypanosoma cruzi Spliceosome Complex

ABSTRACT: The unicellular protists of the group Kinetoplastea include the genera Leishmania and Trypanosoma, which are pathogens of invertebrate and vertebrate animals. Despite their medical and economical importance, critical aspects of their biology such as specific molecular characteristics of gene expression regulation are just beginning to be deciphered. Gene expression regulation mainly depends on post-transcriptional processing, such as the trans-splicing process. Despite being widely used in Trypanosomes, trans-splicing is a rare event in other eukaryotes. We sought to describe the protein composition of spliceosomes in epimastigotes of T. cruzi, the etiological agent of Chagas disease

INSTRUMENT(S): Q-Tof ultima

ORGANISM(S): Trypanosoma Cruzi Cruzi

SUBMITTER: Julia Cunha

LAB HEAD: Patricia Coltri

PROVIDER: PXD018776 | Pride | 2020-05-22

REPOSITORIES: Pride

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Proteomic analysis of Trypanosoma cruzi spliceosome complex.

Barbosa Rosicler L RL da Cunha Julia Pinheiro Chagas JPC Menezes Arthur T AT Melo Raíssa de F P RFP Elias Maria Carolina MC Silber Ariel M AM Coltri Patricia P PP

Journal of proteomics 20200515

The unicellular protists of the group Kinetoplastida include the genera Leishmania and Trypanosoma, which are pathogens of invertebrate and vertebrate animals. Despite their medical and economical importance, critical aspects of their biology such as specific molecular characteristics of gene expression regulation are just beginning to be deciphered. Gene expression regulation also depends on post-transcriptional processing steps, such as the trans-splicing process. Despite being widely used in ...[more]

PMID: 32422275

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