Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
TISSUE(S): Embryo
SUBMITTER: Christian Ihling
LAB HEAD: Elmar Wahle
PROVIDER: PXD018794 | Pride | 2021-09-09
REPOSITORIES: Pride
Cao Wen Xi WX Kabelitz Sarah S Gupta Meera M Yeung Eyan E Lin Sichun S Rammelt Christiane C Ihling Christian C Pekovic Filip F Low Timothy C H TCH Siddiqui Najeeb U NU Cheng Matthew H K MHK Angers Stephane S Smibert Craig A CA Wühr Martin M Wahle Elmar E Lipshitz Howard D HD
Cell reports 20200601 12
In animal embryos, the maternal-to-zygotic transition (MZT) hands developmental control from maternal to zygotic gene products. We show that the maternal proteome represents more than half of the protein-coding capacity of Drosophila melanogaster's genome, and that 2% of this proteome is rapidly degraded during the MZT. Cleared proteins include the post-transcriptional repressors Cup, Trailer hitch (TRAL), Maternal expression at 31B (ME31B), and Smaug (SMG). Although the ubiquitin-proteasome sys ...[more]