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Phophoproteomic identification of kinases downstream of RIPK2

ABSTRACT: Identification of kinases whose activities are regulated by RIPK2 in prostate cancer cells.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

DISEASE(S): Prostate Adenocarcinoma

SUBMITTER: Wei Yang

LAB HEAD: Wei Yang

PROVIDER: PXD018871 | Pride | 2022-02-09

REPOSITORIES: Pride

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Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis.

Yan Yiwu Y Zhou Bo B Qian Chen C Vasquez Alex A Kamra Mohini M Chatterjee Avradip A Lee Yeon-Joo YJ Yuan Xiaopu X Ellis Leigh L Di Vizio Dolores D Posadas Edwin M EM Kyprianou Natasha N Knudsen Beatrice S BS Shah Kavita K Murali Ramachandran R Gertych Arkadiusz A You Sungyong S Freeman Michael R MR Yang Wei W

Nature communications 20220203 1

Despite progress in prostate cancer (PC) therapeutics, distant metastasis remains a major cause of morbidity and mortality from PC. Thus, there is growing recognition that preventing or delaying PC metastasis holds great potential for substantially improving patient outcomes. Here we show receptor-interacting protein kinase 2 (RIPK2) is a clinically actionable target for inhibiting PC metastasis. RIPK2 is amplified/gained in ~65% of lethal metastatic castration-resistant PC. Its overexpression i ...[more]

PMID: 35115556

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