Dataset Information
Label-free proteomic identification of proteins regulated by RIPK2 in PC3 cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
DISEASE(S): Prostate Adenocarcinoma
SUBMITTER: 
Wei Yang
LAB HEAD: Wei Yang
PROVIDER: PXD018890 | Pride | 2022-02-09
REPOSITORIES: Pride
Publications
Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis.
Nature communications 20220203 1
Despite progress in prostate cancer (PC) therapeutics, distant metastasis remains a major cause of morbidity and mortality from PC. Thus, there is growing recognition that preventing or delaying PC metastasis holds great potential for substantially improving patient outcomes. Here we show receptor-interacting protein kinase 2 (RIPK2) is a clinically actionable target for inhibiting PC metastasis. RIPK2 is amplified/gained in ~65% of lethal metastatic castration-resistant PC. Its overexpression i ...[more]
