Dataset Information
Novel Aza-Podophyllotoxin Derivative in Triple Negative Breast Cancer
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: 
Sharon Pitteri
LAB HEAD: Sharon Pitteri
PROVIDER: PXD018929 | Pride | 2020-11-09
REPOSITORIES: Pride
Publications
Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer.
British journal of cancer 20201103 3
<h4>Background</h4>To circumvent Warburg effect, several clinical trials for different cancers are utilising a combinatorial approach using metabolic reprogramming and chemotherapeutic agents including metformin. The majority of these metabolic interventions work via indirectly activating AMP-activated protein kinase (AMPK) to alter cellular metabolism in favour of oxidative phosphorylation over aerobic glycolysis. The effect of these drugs is dependent on glycaemic and insulin conditions. Ther ...[more]
