Effect of HDAC inhibitors on acetylated histones in P. pacificus
Ontology highlight
ABSTRACT: Western Blot showed that epigenetic control of the mouth dimorphism in P. pacificus correlates with histone 4 acetylation. This result was validated by mass spectrometry. This experiment profiled histone acetylation in the presence and absence of the histone deacetylase (HDAC) inhibitor Trichostatin A (TSA). Histone acetylation was also examined in the presence of another HDAC inhibitor (Na-butyrate), which served as an additional negative control because unlike TSA, it did not induce a phenotypic change.
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Pristionchus Pacificus
TISSUE(S): Whole Body
SUBMITTER: Nicolas Nalpas
LAB HEAD: Ralf J. Sommer
PROVIDER: PXD018940 | Pride | 2023-02-24
REPOSITORIES: Pride
ACCESS DATA