Effect of HDAC inhibitors on acetylated histones in P. pacificus

ABSTRACT: Western Blot showed that epigenetic control of the mouth dimorphism in P. pacificus correlates with histone 4 acetylation. This result was validated by mass spectrometry. This experiment profiled histone acetylation in the presence and absence of the histone deacetylase (HDAC) inhibitor Trichostatin A (TSA). Histone acetylation was also examined in the presence of another HDAC inhibitor (Na-butyrate), which served as an additional negative control because unlike TSA, it did not induce a phenotypic change.

INSTRUMENT(S):

ORGANISM(S): Pristionchus Pacificus

TISSUE(S): Whole Body

SUBMITTER: Nicolas Nalpas  

LAB HEAD: Ralf J. Sommer

PROVIDER: PXD018940 | Pride | 2023-02-24

REPOSITORIES: Pride