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Proteomic study of low-birth-weight nephropathy molecular pathogenesis in rats

ABSTRACT: We investigated the molecular pathogenesis of LBW rats obtained by intraperitoneal injection of dexamethasone into pregnant animals. Normal-birth-weight (NBW) rats were used as controls with seven animals per group. When the rats were four weeks old, the left kidneys were removed and used for comprehensive label-free proteomic studies

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Kidney

SUBMITTER: Stephane Claverol

LAB HEAD: Marc Bonneu

PROVIDER: PXD018948 | Pride | 2022-02-15

REPOSITORIES: Pride

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Proteomic Study of Low-Birth-Weight Nephropathy in Rats.

Imasawa Toshiyuki T Claverol Stéphane S Lacombe Didier D Amoedo Nivea Dias ND Rossignol Rodrigue R

International journal of molecular sciences 20210924 19

The hyperfiltration theory has been used to explain the mechanism of low birth weight (LBW)-related nephropathy. However, the molecular changes in the kidney proteome have not been defined in this disease, and early biomarkers are lacking. We investigated the molecular pathogenesis of LBW rats obtained by intraperitoneal injection of dexamethasone into pregnant animals. Normal-birth-weight (NBW) rats were used as controls. When the rats were four weeks old, the left kidneys were removed and used ...[more]

PMID: 34638634

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