Cortical actin tension regulates secretory protein trafficking and the endoplasmic reticulum stress response

ABSTRACT: We used proximity-based biotinylation assay cells to isolate candidate plasma membrane-associated proteins whose localization are sensitive to cortical tension level. Using membrane-targeting ascorbate peroxidase (APEX2-CAAX) as a bait, we mapped the proteomic landscape at the cell cortex under high and low cortical tension conditions.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Mammary Epithelial Cell, Epithelial Cell, Cell Culture

SUBMITTER: Hector Huang  

LAB HEAD: Arun P. Wiita

PROVIDER: PXD018975 | Pride | 2022-06-10

REPOSITORIES: Pride