Effects of Canavanine on Human Glioblastoma Cells under Arginine Deprivation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
DISEASE(S): Brain Cancer
SUBMITTER: 
Pavel Shliaha
LAB HEAD: Ole N Jensen
PROVIDER: PXD019044 | Pride | 2020-10-19
REPOSITORIES: Pride
Publications
Combinatory Treatment of Canavanine and Arginine Deprivation Efficiently Targets Human Glioblastoma Cells via Pleiotropic Mechanisms.
Karatsai Olena O Shliaha Pavel P Jensen Ole N ON Stasyk Oleh O Rędowicz Maria Jolanta MJ
Cells 20200930 10
Glioblastomas are the most frequent and aggressive form of primary brain tumors with no efficient cure. However, they often exhibit specific metabolic shifts that include deficiency in the biosynthesis of and dependence on certain exogenous amino acids. Here, we evaluated, in vitro, a novel combinatory antiglioblastoma approach based on arginine deprivation and canavanine, an arginine analogue of plant origin, using two human glioblastoma cell models, U251MG and U87MG. The combinatory treatment ...[more]
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