Effects of Canavanine on Human Glioblastoma Cells under Arginine Deprivation

ABSTRACT: We investigated the effect of canavanine (toxic Arg analogue) treatment on U251MG and U87MG cell lines using a variety of methods including proteomics. Since 3rd isotope of unmodified peptide cannot be resolved from canavanine containing peptide even at extremely high resolutions of 480K we incorporated R13C615N4 into peptides to avoid MS1 overlap of Arg signals.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Brain Cancer

SUBMITTER: Pavel Shliaha  

LAB HEAD: Ole N Jensen

PROVIDER: PXD019044 | Pride | 2020-10-19

REPOSITORIES: Pride