Dataset Information

Colorectal cancer proteome project for biomarke search and development of clinical test

ABSTRACT: To find differentially expressed protein in colorectal cancer compared with normal colon tissue, we performed global proteome analysis using LC-MS.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Colon

DISEASE(S): Colon Cancer

SUBMITTER: Atsushi Tanaka

LAB HEAD: Michael H. A. Roehrl

PROVIDER: PXD019103 | Pride | 2020-09-30

REPOSITORIES: Pride

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Publications

Maspin as a Prognostic Marker for Early Stage Colorectal Cancer With Microsatellite Instability.

Tanaka Atsushi A Wang Julia Y JY Shia Jinru J Zhou Yihua Y Ogawa Makiko M Hendrickson Ronald C RC Klimstra David S DS Roehrl Michael H A MHA

Frontiers in oncology 20200610

Colorectal cancers are among the most common cancers and a leading cause of cancer death. In our pursuit to discover molecular markers for better characterization and precision theranostics of these cancers, we first conducted global deep proteome analyses and identified maspin (serpin B5, peptidase inhibitor 5) as an upregulated protein in tumor tissue. We then validated its expression in a large cohort of 743 patients with colorectal cancers of all stages and found that both cytoplasmic and nu ...[more]

PMID: 32587829

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Dataset Information

Colorectal cancer proteome project for biomarke search and development of clinical test

Publications

Maspin as a Prognostic Marker for Early Stage Colorectal Cancer With Microsatellite Instability.

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