Histone post-translational modifications of Trypanosoma cruzi: a high-confidence comprehensive map

ABSTRACT: In humans and other eukaryotes, histone post-translational modifications (hPTMs) play an essential role in the epigenetic control of gene expression. In trypanosomatid parasites, conversely, gene regulation occurs mainly at the post-transcriptional level. However, our group has recently shown that hPTMs are abundant and varied in Trypanosoma cruzi, the etiological agent of Chagas Disease, signaling for possible conserved epigenetic functions. Here, we provide a high-confidence comprehensive map of hPTMs, distributed in all canonical, variant and linker histones of T. cruzi. Our updated landscape expands the number of known T. cruzi hPTMs by almost 2-fold, representing the largest dataset of hPTMs available to any trypanosomatid to date, and can be used as a basis for functional studies on the dynamic regulation of chromatin by epigenetic mechanisms and the selection of candidates for the development of epigenetic drugs in trypanosomatids.

INSTRUMENT(S): LTQ Orbitrap XL ETD

ORGANISM(S): Trypanosoma Cruzi

DISEASE(S): Chagas Disease

SUBMITTER: Lyris de Godoy  

LAB HEAD: Lyris Martins Franco de Godoy

PROVIDER: PXD019104 | Pride | 2021-01-04

REPOSITORIES: Pride