Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Heart Valve
DISEASE(S): Infective Endocarditis
SUBMITTER: Daniel Martin
LAB HEAD: Suneel Apte
PROVIDER: PXD019129 | Pride | 2020-07-29
REPOSITORIES: Pride
JCI insight 20200723 14
Infective endocarditis is a life-threatening infection of heart valves and adjacent structures characterized by vegetations on valves and other endocardial surfaces, with tissue destruction and risk of embolization. We used high-resolution mass spectrometry to define the proteome of staphylococcal and non-staphylococcal vegetations and Terminal Amine Isotopic Labeling of Substrates (TAILS) to define their proteolytic landscapes. These approaches identified over 2000 human proteins in staphylococ ...[more]