SARS-CoV-2 induced glycolysis is essential for monocytes inflammatory response
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Monocyte, Cell Culture, Macrophage
DISEASE(S): Covid-19
SUBMITTER: 
Victor Corasolla Carregari
LAB HEAD: Daniel Martins-de-Souza
PROVIDER: PXD019157 | Pride | 2021-09-09
REPOSITORIES: Pride
Publications
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis.
Codo Ana Campos AC Davanzo Gustavo Gastão GG Monteiro Lauar de Brito LB de Souza Gabriela Fabiano GF Muraro Stéfanie Primon SP Virgilio-da-Silva João Victor JV Prodonoff Juliana Silveira JS Carregari Victor Corasolla VC de Biagi Junior Carlos Alberto Oliveira CAO Crunfli Fernanda F Jimenez Restrepo Jeffersson Leandro JL Vendramini Pedro Henrique PH Reis-de-Oliveira Guilherme G Bispo Dos Santos Karina K Toledo-Teixeira Daniel A DA Parise Pierina Lorencini PL Martini Matheus Cavalheiro MC Marques Rafael Elias RE Carmo Helison R HR Borin Alexandre A Coimbra Laís Durço LD Boldrini Vinícius O VO Brunetti Natalia S NS Vieira Andre S AS Mansour Eli E Ulaf Raisa G RG Bernardes Ana F AF Nunes Thyago A TA Ribeiro Luciana C LC Palma Andre C AC Agrela Marcus V MV Moretti Maria Luiza ML Sposito Andrei C AC Pereira Fabrício Bíscaro FB Velloso Licio Augusto LA Vinolo Marco Aurélio Ramirez MAR Damasio André A Proença-Módena José Luiz JL Carvalho Robson Francisco RF Mori Marcelo A MA Martins-de-Souza Daniel D Nakaya Helder I HI Farias Alessandro S AS Moraes-Vieira Pedro M PM
Cell metabolism 20200717 3
COVID-19 can result in severe lung injury. It remained to be determined why diabetic individuals with uncontrolled glucose levels are more prone to develop the severe form of COVID-19. The molecular mechanism underlying SARS-CoV-2 infection and what determines the onset of the cytokine storm found in severe COVID-19 patients are unknown. Monocytes and macrophages are the most enriched immune cell types in the lungs of COVID-19 patients and appear to have a central role in the pathogenicity of th ...[more]
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